Research collaboration between University of Hyderabad (UoH), National Institute of Nutrition (NIN) and IKP Knowledge Park over the last two years has culminated in the successful completion of a pre-clinical study on anticancer drug Temozolomide in animal models.
Temozolomide is the only drug approved for brain tumor, known as glioblastom multiforme in scientific term. The stability of this potent chemotherapy drug is compromised due to degradation in storage and shelf handling, causing dark brown discoloration of the drug powder. This problem is more acute in the hot and humid tropical countries of the world, including Asia, Far East and Latin America.
The research group of UoH developed stable form of Temozolomide which also overcomes the discoloration problems. Then in collaboration with NIN, they tested the stable Temozolomide with the reference drug in animal models to establish bioequivalence and bioavailability and drug transport.
This collaborative project is a success story of the ‘Knowledge-to-Equity Program’ of the Ministry of Science and Technology as part of which academic discoveries get a platform for drug translation to the market in PPP model.
[Credit – TOI]